Disorders 1 Division of Reproductive Endocrinology, Women's Health and Musculoskeletal Biology, Wyeth Research, Collegeville, Pennsylvania, 2

Disorders 1 Division of Reproductive Endocrinology, Women's Health and Musculoskeletal Biology, Wyeth Research, Collegeville, Pennsylvania, 2 and 3 translational Biological Research Technologies, Wyeth Research, Cambridge, Massachusetts, 4 Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, 5 Department of Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, Texas, and 6 detection and Chemistry, Wyeth Research, Pearl River, New York, Applications br reprints: Scott A. Jelinsky, Wyeth Research, 200 Cambridge Park Drive, Cambridge, MA 02140. Phone: 6176655366, Fax 6176655320, Email: sjelinsky (a) wyeth.com. br uterine leiomyomas or fibroids are benign tumors of the uterine myometrium significantly affect up to 30% of women of reproductive age. Despite being the leading cause of hysterectomy in the United States, representing up to 200,000 procedures per year, the etiology of leiomyoma remains largely unknown. As a basis for understanding the pathogenesis of leiomyoma and identification of the objectives of drug treatment was performed transcriptional profiling of leiomyoma and unaffected myometrium of Eker rats and humans, the best characterized preclinical model for leiomyomas. A global comparison of mRNA versus human leiomyoma and myometrium of rat identified a large significant overlap of gene expression deregulation in leiomyomas. A pathway analysis using a fair method of enrichment geneset algorithm based on the detected target sigPathway mammalian rapamycin (mTOR) pathway as one of the most regulated pathways in both human and rat tumors. To validate this pathway as a therapeutic target for uterine leiomyomas, were conducted preclinical studies in rats Acar. These rats develop uterine leiomyomas, following the loss of TSC2 function and regulation of mTOR signaling. Inhibition of mTOR in female rats with rapamycin Eker similarly129327 for 2 weeks decreased mTOR signaling and cell proliferation in tumors, and treatment for 4 months significantly reduced tumor incidence, multiplicity and size. These results identify the deregulation of mTOR signaling as a component of the etiology leiomyoma among species and shows directly the dependence of uterine leiomyomas with the mTOR signaling pathway active in this growth. [Cancer Res 2009; 69 (15): 61,718] br br br br

Female infertility is a major problem for many women, mainly due to a desire for a

Female infertility is a major problem for many women, mainly due to a desire for a child of their own. This condition is fairly easy to detect in women and men, especially when it comes to conceiving a child. The signs of female infertility can be seen by a doctor immediately after careful examination and diagnosis of women. There are also some signs of female infertility not appear to be associated with infertility. After a full medical diagnosis should be considered as signs of female infertility. br In addition to being able to conceive or carry a pregnancy to term, other signs of menstrual cycles of female infertility are irregular, abnormal weight loss or gain, excessive hair growth, recurrent acne of puberty, menstruation and pain during intercourse and irregular basal body temperature. br an irregular menstrual cycle may be a sign of female infertility because it can mean harm, obstruction or damage to parts of the female reproductive system. Excessive bleeding is the cause of female infertility, in the sense that there is something wrong with the shape of a woman's menstrual cycle in particular. The absence of menstruation can also indicate that infertility may not eggs produced by women. br fluctuations in weight, hair growth and acne irregular over the age of puberty are also signs of female infertilitybecause sometimes are caused by hormonal imbalances that can affect the female reproductive system. Hormones control many of the basic functions of our body and an imbalance in this regard can cause a lot of irregularities in the body. In particular, painful menstrual cramps can also be signs of female infertility and endometriosis that can cause signal blockage or damage to the parts of a womans reproductive system. Endometriosis can cause pain during intercourse, and fibroids, which may block the passage in and around the reproductive system. br basal body temperature is taken to check when a woman is most fertile and when not. Irregular, basal body temperature is included in the signs of female infertility. Some women may be infertile can have basal body temperature, which fluctuate erratically or does not reach the level that indicates fertility. These signs br of female infertility are the most basic. There are other signs of female infertility that can be seen after the doctor has done a thorough analysis of responses. br br br br

Unusual mucus or other substances in the vagina is a common problem and this flow is

Unusual mucus or other substances in the vagina is a common problem and this flow is usually due to an infection and is associated with pain, burning, itching and painful urination. It is not necessary that all sexually transmitted infections and therefore should not assume that the vagina is always a STD.Irritation of the vagina, also known as vaginitis is the most common reason for discharge and is usually caused by infection. There are three main types of vaginal infections and these all could be treated with medication by mouth or vaginally. Such infection tends to produce a separate download: 1. Usually there is a thick, white cheese like discharge that is itchy, irritated skin, yeast infection or candidiasis. Women who have diabetes and those who take antibiotics are more likely to develop the infection. Most women face at least one yeast infection at some point in their lives. 2. There is a thin, yellow, foul smelling, also known as sexually transmitted trichomonas. 3. Other symptoms are thin, gray or white, foul smelling discharge known as the inflammatory disease is frequently caused vaginosis.Pelvic sexually transmitted bacterial disease that infects the cervix, uterus, ovaries or fallopian tubes and is one of the most common and serious complications of sexually transmitted diseases. Symptoms include vaginal discharge or bleeding, abdominal pain and fever. Chronic PID can result in one or more infections and the most common symptoms that can be identified are gonorrhea or Chlamydia are sexually transmitted.Genital herpes can also cause vaginal discharge and can affect the cervix. It includes features such as fever, pruritus, headache and muscle aches in general. Some women also have an infection inside the uterus, a condition called endometriosis that causes fibroids, cancer or STDs.Sometimes a hole develops in the vagina and the passage of stool or urine caused passes through the vagina . This problem may develop after surgery or injury to the area, infection, inflammation or radiation.Inflammation in the vagina is also caused by lack of estrogen and when a woman enters menopause, her body produces more estrogen and more erratic. This often makes the vagina dry and irritated. This condition is also known as atrophic vaginitis and could be treated with estrogen replacement therapy, vaginal creams or vaginal suppositories.For more information, visit the womensreproductivehealth.info br br br br

I knew he was there at 2 in the morning, soaking through a tampon Superplus and

I knew he was there at 2 in the morning, soaking through a tampon Superplus and two night tables had recorded together, which would be another sleepless night. I was afraid to get out of bed to switch providers. I had ruined enough underwear, nightgowns and blankets during the previous year to know that any sudden movement, even rolling in bed, could cause a large airplane. However, I made gradually squeezing the legs together, as I rose to cross the bedroom floor. The blood ran down my thighs and on the carpet while I seek my way in the dark to the bathroom. The help was on the road. At least three hours. Bleeding profusely br three days a month, loss of sleep, keep a change of clothes at work, unable to concentrate because of my anemia and depletion of total new normal for me. As a single mother raising two teenage girls and two jobs, it was a disaster. If not for the love and support of my children, my family, my boyfriend and my boss, I probably would have lost my job and my sanity. I needed help and needed it fast. Enough is enough, I thought as I rolled to my family doctor for the third time in a year. quot; I can not make this m bleeding; squot never, I said. quot; And I quot; medication prescribed Cyklokapron thickening of the blood, I was going to take every four hours during the day of my heaviest. He also sent me an ultrasound, which revealed multiple fibroids growing inside the lining of my uterus, one as big as an orange, and each time more per month. Fibroids (now know) are noncancerous tumors that develop on or in the lining of the uterus and can cause severe bleeding, extreme pain or, for some lucky women, no symptoms at all. Approximately 40 percent of Caucasian women and 60 percent of African American women have fibroids than 35 years of age, with a growing number by 70 percent and 80 percent, respectively, for 50 years. Nobody really knows what causes, but estrogen makes it grow, fortunately, usually continue to increase in size after menopause. Only three of the options my doctor referred me to a gynecologist, who said there were three options to manage my menopause symptoms, increase my dose of Cyklokapron or a partial hysterectomy to remove my womb. quot; The uterus is like a tree illuminated Navidadquot he said, referring to my ultrasound, which seemed a screen LiteBrite, with many colored dots indicating where the fibroids. He described the uterus like a nest of quot; c; ncerquot, and said that a hysterectomy is the only sure way to eliminate any risk of developing cancer of the uterus in the road, although he had no family history of it or any other cancer. With this language, I got in I called my boyfriend on the way home, crying, quot; Gaston, I think it must have a histerectom; a.quot, was exhausted and tired, my brain was in a fog, and is currently at the prospect of major surgery. I thought about it and after my next period even heavier, decided to call my gynecologist to the book of surgery. Sue My sister told me I was crazy. I had heard all kinds of stories about women who had experienced health problems after hysterectomy. I ignored him, saying it was my body and I could choose any treatment that I wanted. After all, I knew there were several women, the procedure and raved about its results. One of them is my friend Louise, who, like me, lives in Ottawa. She told me that the surgery gave him a new life after years of heavy bleeding and terrible pain caused by endometriosis. quot; I suffered for 20 years and over with the only class that, like most women, quot; Louise confidence. quot; One morning I woke up and my back pain was so bad I had to crawl to the bathroom. Was too much. I went to my doctor and asked for a hysterectomy. She says she has never looked back. He was jealous and wanted the same relief. br br br br

News Room raquo Blog Archive raquo Nishs blog, so ... if

News Room raquo Blog Archive raquo Nishs blog, so ... if the ovaries have been removed or not br My memory is horrible! Sometimes he enters the bathroom and forget why I'm there ... What's wrong raquo; BR The question came from a patient who was scheduled to see a gynecologic surgeon later that week. The cysts had a hysterectomy to resolve years of irregular bleeding, along with the development of fibroids, and ovarian cancer. However, this patient had not received any evidence of the hormone or a history of hormone balance in the previous programming of this radical surgical procedure. br The question arose in a moment, but would not change my answer today women have said for years about the removal of the ovaries, we now have a new study that supports my recommendation. br A study in the May 2009 edition of Obstetrics and Gynecology, made a strong argument against the advice often given to women facing the same prognosis for the removal of the ovaries was made. br majority of doctors have taken the route that removing the ovaries at the time of hysterectomy will help save women from ovarian cancer later in life. This advice, of course, is often welcomed by women as ovarian cancer is one of the most feared by women today. But the reality is that only 3% of ovarian cancer of all cancers and only 1% of all deaths of women. This is a rare type of cancer. BR A recent study showed that women who had a hysterectomy and ovaries removed before age 50 almost doubled the risk of heart disease and stroke. In addition, women who choose to undergo a hysterectomy and ovaries before age 50 increased their risk of premature death by 40%! br My answer to this does not always work, but if we can help balance hormones, when problems arise, and women suffering from hormonal imbalance reverse estrogen key problems such as fibroids, fibrocystic breasts, SOP, irregular bleeding, endometriosis, etc, then the need to remove the ovaries, some time should be less of a concern and, finally, reduce the risk of heart disease, stroke and premature death! br women should be tested and have options! How hormonally balanced before hysterectomy can be a very positive option for women often resolving their symptoms. br br br br

OverviewChasteberry or Vitex, is mostly used in the treatment of premenstrual syndrome, but a list of

OverviewChasteberry or Vitex, is mostly used in the treatment of premenstrual syndrome, but a list of applications for which there is no clinical evidence includes: hyperprolactinemia, corpus luteum insufficiency, infertility associated with corpus luteum insufficiency, mastodynia, premenstrual tension syndrome (ULTT), symptoms of perimenopause, fibroids, endometriosis (adjuvant therapy), Parkinson's disease, stimulation of milk production, reducing the production of surplus milk in infancy, and acne (McKenna et al., 2001). The chemistry of Vitex (V. Agnuscastus) is still not understood, nor the relationship of chemical components for therapeutic use. Standardized extracts of Vitex have had extensive clinical research. Standardization is usually 0.5% of agnusides fruit extract 20:1. The fruit, leaves and seeds of the plant Vitex have documented the use of traditional medicine, but modernday extracts of focusing only on fruits. Known chemical compounds in fruits are essential oils (0,151,0%), consisting of 73 compounds identified, including 4terpineol, pinene, phellandrene, sabinene, caryophyllene, farnesene oxide of caryophylline E, alloaromadenedrene and spathulenol, and flavonoids, including orientin, isoorientin, xyloside, vitexin and isovitexin (McKenna et al., 2001). Vitex has dopaminergic activity that inhibits the activity of prolactin. It is this activity which is mainly due to therapeutic applications (McKenna et al., 2001). Some of the most remarkable preclinical summary estrogenic activity has been reported for the equivalent of one third of the dose given to humans overiectomized female rats (Eagon et al., 1997). Several parts of the plant Vitex (most of the leaves and fruits) have shown antimicrobial activity or growth inhibitors against Pseudomonas aeruginosa, Escherichia coli, Bacillus subtilis, Staphylococcus aureus, Aspergillus parasiticus, Candida krusei, C. albicans, Penicillium viridactum, Streptococcus faecalis, Trichophyton mentagrophytes, Microsporaum gypseum, M. canis, Shigella sonei, Epidermophyton floccosum and common insect pests (Snow, 1996; Pepeljnjak et al., 1996; and Kustrak et al., 1997). A dopamine agonist action is exhibited by Vitex which then produces a antiprolactin in hypothalamuspituitary axis, however, research has found Vitex not expand the size of the secretion of dopamine (McKenna et al., 2001; Wuttke et al. 1995). Concentrationdependent reduced prolactin secretion in isolated rat pituitary cells in vitro was found using Agnolyt (Wuttke, 1992). CommentsVitex is only the second in popularity with black cohosh for women's health. Although Vitex is generally regarded as a key drug for premenstrual syndrome, also support clinical symptoms of menopause, including women SupportClinical Vitex complaints.Scientific research has been ongoing since the 1930s, with the earliest work in progress on its reputation as a galactogogue by Madusa with your product, Agnolyt (McKenna et al., 2001). BalancingCorpus hormone insufficiency luteum (CLI) is a condition in which blood levels of progesterone are low 3 weeks after the onset of menstruation (less than 1012 ng / ml). The symptoms of menstruation may be long, anovulatory periods (with the resulting infertility), PMS and mastopathy. The underlying cause is believed to hyperprolactinemia (McKenna et al., 2001). Vitex clinical work carried out in various menstrual symptoms, including premenstrual syndrome (PMS), premenstrual tension syndrome (ULTT) and CLI. Because of the similarity of syndromes and symptoms, the groups involved may represent a mixture of these diagnoses.The tolerance and the effect of high doses of Vitex extract was studied in 20 healthy men, 2032. The men were selected for this study, while prolactin levels are lower because fewer women are hormonal changes. The extracts were described as nonalcoholic extracts waterand mostly prepared from nuts thick couples agnuscastus V. (BP1095E1 special extract). The analysis of the results of the lower dose to reduce serum prolactin 24 hours over 15% and 21% on average and extracts the highest dose. Both dopamine agonist and antagonist actions are suspected, the antagonistic actions that take place with the lowest dose of Vitex. The extract was judged to be well tolerated and no significant effects were observed, and only temporary or idiosyncratic adverse effects were observed (Merz et al., 1996). A study of 52 women with latent hyperprolactinemia found that Vitex therapy (20 mg / day) produced lower levels of prolactin and the normalization of the levels of other hormones associated with the menstrual cycle. Vitex has also been found to significantly reduce symptoms of premenstrual syndrome in women who had presented at baseline. No side effects were found in the study, and two of the 17 women became pregnant, Vitex group (Milewicz et al., 1993). In another study of 13 women with hyperprolactinemia and cyclic disorders, a product called Vitex Mastodynon was tested. After three months of the study, prolactin levels were measured and found to have decreased, and some within the normal range of prolactin secretion. The women's menstrual cycle on Vitex therapy was also found to be normalized (Roeder, 1994). The use of Vitex (Agnolyt, 40 drops / day for 3 months) has been tested in an uncontrolled open study of 20 infertile women with no imbalance of prolactin. Prolactin, thyroid hormones and androgens in normal women selected for this study, but all had low progesterone levels on day 20 of the menstrual cycle. At the end of the study, progesterone levels rose to normal ranges in 7 women, and in 4 cases, progesterone levels rose above normal. Furthermore, basal body temperature rose, and women had a long phase of hyperthermia on normal cycles. Two of the women became pregnant, and no side effects (shoring and Katzork, 1987). Doubleblind In one study, placebocontrolled of 52 women with abnormal menstrual cycles and CLI, Vitex extract was administered for 3 cycles (Strotan, 20 mg / day). In the treatment group, the luteal phase had changed from an average of 5.5 days to 10.5 days, and stage of follicle was reduced from 23.8 days to 18.5 days. Furthermore, prolactin levels normalized (previous high), and there were significant increases in both estrogen and progesterone levels compared with placebo. An additional benefit of the study was that the three women who were previously unable to conceive became pregnant (Bubenzer, 1983). A series of large monitoring studies reported drug use Vitex (as drops Agnolyt) (McKenna et al., 2001): Results of a questionnaire reported the use of Vitex (several formulations) of 153 members of the National Institute of Herbal Medicine in England and Ireland. The treatments were reported for premenstrual syndrome (94.1%), perimenopausal complaints (86.3%), female infertility (89.5%), acne and female (79.7%), acne and male (10 , 5%). 98.6% of respondents believe Vitex be very effective or effective for syndromes of hormonal imbalance. The average duration of treatment for PMS = 4.8 months and for menopausal complaints = 7.1 months. The most common preparation used was dye (86.4%), followed by fluid extracts (28.1%) and herbal preparations powder (9.2%). Very few physicians use standardized extracts powder (Christie and Walker, 199798). Agnolyt A multicenter study using cases recorded in 1592 for menstrual disorders and PMS (usually with corpus luteum insufficiency). The mean treatment was 43 drops for 5 months. A good or satisfactory response was reported in 90% of cases. There were 145 patients who have expressed their desire to become pregnant, and 56 of them did. 2.4% of cases of side effects (Keep et al., 1991). Two drugcontrol studies reported using drops Agnolyt. A total of 3162 women were followed, most with some type of menstrual problem. Diagnoses included PMS (1,016 women), the inadequacy of the corpus luteum (734 women), fibroids (320 women) and symptoms of menopause (167 women). The mean treatment was 153 days, using 42 drops daily Agnolyt. Treatment efficacy was observed in 90%, 1% of the side effects experienced (Loch et al., 1991). Use Agnolyt recorded in 1571 women for menstrual problems associated with corpus luteum insufficiency or ovarian dysfunction. Average treatment was 40 drops per day on an empty stomach, and lasted for 135 days. A response rate of almost 90% was recorded with adverse effects in only 1.9% of women (Feldmann et al., 1990). In a followup drug Attleman et al. (1972) on the use of Vitex (Agnolyt) in general and consulting practices of the authors in Germany. More than 2,000 cases analyzed, using Vitex for PMS, menorrhagia, hypermenorrhea (due to uterine fibroids), headaches (to control the use of birth control pills), mastopathia, amenorrhea (primary and secondary), uterine bleeding (juvenile ), bleeding menopause, and infertility. Most treatments for menopause 40 drops per day, after meals. Adverse effects were reported as rare.PMSAn Vitex extract (Ze 440; a daily 20 mg of the extract to native menstrual cycles during 8) was administered to 50 patients with premenstrual syndrome in a prospective multicenter study. Treatment results were monitored using the validated questionnaire Moos menstrual distress (MMDQ), a visual analogue scale (VAS, self) and a global impression scale. The PMS symptoms were found to be reduced by treatment for a significant reduction in MMDQ score of 42.5%. The overall efficacy results was good to excellent (in 38 patients), and the number of days of symptoms of premenstrual syndrome have decreased slightly, from 7.5 to 6 days. There were no differences between patients of oral contraceptives in comparison with others, and without significant side effects were found (Berger et al., 2000). A solid preparation of extract of Vitex was tested again for 3 menstrual cycles in women in a large multicenter study. 1634 patients were administered a questionnaire to more common PMS symptoms, and 93% reported a decrease or disappearance of symptoms of PMS. 85% of physicians reported the efficacy of the treatment, while 81% of patients rated good or very good as or even better. No serious side effects were recorded (Loch et al., 2000). A doubleblind, placebocontrolled, randomized trial of Vitex on 600 (including the placebo groups), women with premenstrual syndrome were reported. Participants were judged using the Menstrual Distress Questionnaire. A significant improvement was found in the sense of nervousness or anxiety symptoms, but otherwise, the authors concluded the effectiveness of Vitex to be better than placebo (soybean). The authors also acknowledged that the study design may have unfairly skewed the results of the differences between the treatment groups and control (Turner and Mills, 1997). In a study published by the premenstrual tension syndrome (ULTT) was conducted in a multicenter, randomized, doubleshaped center involving 105 women. Effectiveness was assessed in 77.1% of Vitex and 60.6% of pyridoxine (by the Clinical Global Impression scale). Although the results were invalid statisitically, the authors support the overall performance benefits Agnolyt (Lauritzen et al., 1997). Another study examined the effectiveness of Agnolyt capsules (of a new preparation at the time) in TTES. The study was randomized, double blind, using 175 mg daily against pyridoxine (vitamin B6, 200 mg / day) in 175 women. Treatment continued for 3 cycles, and qualified with the scale of TTES. In the treatment group, fell TTES points from 15.2 to 5.1 points after treatment, and 11.9 to 5.1 points in the pyridoxine group (reflecting a significant improvement in symptoms). Assessments of patients were 36.1% for Vitex versus 21.3% of pyridoxine, and medical evaluations Vitex 24% reported excellent compared with 12.1% of pyridoxine (Reuter et al., 1995) . In a study of 1542 women Vitex drug control is used to treat various disorders such as premenstrual syndrome, corpus luteum insufficiency, uterine fibroids, and the symptoms of menopause. 20,120 was used Agnolyt falls by an average of 42 drops per day over a period of 7 days to 16 years. Symptom improvement began after an average of approximately 25 days, and the dissatisfaction rate was only 4.5% for consultants and patients (Dittmar et al., 1992). Madusa AcneThe company is the manufacturer of Agnolyt one of the most popular Vitex preparations in Europe. In its prospectus (1994) describe several clinical studies. One use for the experiments are recorded for the treatment of acne. In one, Agnolyt was used to treat 118 patients in 1224 months. This treatment group was compared with a group of 43 patients who received conventional treatment. Vitex end of the study group that have healed faster and had fewer relapses than those of conventional treatment. Men and women are described as candidates for the treatment of acne in the brochure Vitex Madusa (McKenna et al., 2001). LactationVitex has historically been used to carry lactation in women who are having trouble producing milk. The exact mechanisms of hormones involved in lactation are complex and not fully understood, and similarly, the use of Vitex to breastfeeding has been controversial because of our lack of understanding of their actions. Breastfeeding women with high prolactin levels and suppressed ovulatory function often show symptoms associated with follicular development, corpus luteum disorganized and inadequate. More than half of all women with menstrual problems (62%) also have abnormally high levels of prolactin. The reverse is also true that women are almost always hyperprolactinemic menstrual disorders (B Hnert, 1997). PainHalaska Seno et al. (1998) Vitex extract administered to patients with a doubleblind mastodynia, placebocontrolled. Two parallel groups of 50 patients were treated for 3 menstrual cycles (60 drops of Vitex extract daily or placebo). The intensity of breast pain was found to decrease more rapidly in Vitex treatment groups versus placebo, and tolerability of treatment was found to satisfactory.In doubleblind a randomized, placebocontrolled, multicenter using Vitex (Mastodynon N ) has been tested in women with cyclical mastalgia. 120 women (ages 2340) who had presented with breast pain for 3 or more cycles (for 3 or more days of cycle) in the study. A parallel group design and technology doubledummy was used in the study, using a tablet and form of liquid extract of Vitex, and matching placebos. Prolactin levels were measured during the study, and participants were evaluated with a linear analog scale (VAS). Both the form of tablets (3.7 ng / ml, p = 0.015) and fluids (4.35 ng / ml, p = 0.039) of Vitex produced significant decreases in prolactin levels in the subjects. Vitex Liquid preparation was found to produce changes more quickly than the tablet, and none of the preparations for the changes in FSH, LH and progesterone. The symptoms of headache, abdominal pain, psychological symptoms, and a tendency to edema were reduced in the treatment groups compared with placebo, and the number of days without pain increased by 15% in treatment groups compared with 8% in the placebo group. Estradiol levels were found to increase the treatment groups (25.7 pg / mL for the tablet, and 28.5 pg / NL for liquids) compared with placebo (10.8 ng / ml). Besides this study, small studies have reported good results for the use of Vitex in mastalgia treatment (Kubista et al., 1983 and Wuttke et al., 1995). / Security DosageMost studies of black cohosh have used brand names as Agnolyt (liquid or capsules) Strotan or Mastodyne. Dosage recommendations for the various preparations are (McKenna et al., 2001): Agnolyt liquid (58% alcohol, 100 g of solution containing 9 g of dye from berries (1.5)) 40 drops a day after meals for several months. Agnolyt capsule (175 mg dried berries, alcoholic extract 1:5) once daily for several months.Standardized juice powder (175 mg 20:1 fruit extract, standardized to agnusides 0.5%) one capsule a day, which is a common preparation in the U.S. and is similar to the capsules formulation.Strotan Agnolyt capsule (20 mg of alcohol extract, 5070% v / v) daily.Mastodyne time (ethanolwater extract containing 55.4% ethanol by volume) 60 drops side effects daily.Serious have been cited for Vitex, but the rashes and itching have been reported. Although there are no contraindications are found in the monographs of the German Commission E, others have expressed concern the use of Vitex in conjunction with oral contraceptives. Due to recently discovered the dopamine agonist activity of Vitex, can be a problem with people taking Vitex which are also dopamine antagonists (McKenna et al., 2001). A review of the literature cites various opinions about the use of Vitex to pregnancy (especially in the initial phase), but in general is usually contraindicated. Reports of possible negative reactions to Vitex in women undergoing IVF have been cited. Vitex use during lactation has also been of mixed opinion (McKenna et al., 2001). References1.Attelman H, K Bends, Hellenkemper H, et al. Agnolyt in treating gynecological complaints. Zeitschrift f r Praklinishche Geriatrie. 1972, 2:239 (translation) .2. Berger D, Schaffner W, Schrader E, Meier B, Brattstrom A. Efficacy of Vitex agnus castus L. extract Ze 440 in patients with premenstrual syndrome (PMS). Arch Gynecol Obstet. 2000 Nov; 264 (3): 1503 .3. B Hnert KJ. Clinical study on Vitex for menstrual disorders. Quarterly Report of Natural Medicine (Spring) 1997; 1921.4.Christie S, Walker, AF. Agnuscastus Vitex L. (1) a review of its therapeutic use traditional and modern (2) the current use of a survey of professionals. The European Journal of 199,798 herbal medicine, 3: 29 45.5.Dittmar FW, Bohnert KJ, Peeters M. et al. The treatment of premenstrual syndrome with the PPP. Gyn Therapiewoche kologie 1992, 5:6068 (translation) .6. Eagon CL, Elm MS, Teepe AG, Eagon PK. Medical botany: estrogenicity in rat uterus and liver. Proceedings of the American Association for Cancer Research, 1997, 38: 293 (1967 summary) .7. Feldman, HU, Albrechet M, Lamertz M. et al. The treatment of corpus luteum insufficiency and premenstrual syndrome. Experience in a multicenter study on the conditions of clinical practice. Gyne 1990; 12:422425 (translation) .8. Halaska M, Raus K, Beles P, Martin A, Paithner KG. Treatment for cyclical breast pain using a Vitex agnus extract: results of a comparison with placebo doubleblind. Ceska Gynekol. 1998 Oct; 63 (5): 38,892 .9. Krustrak D Kuftinec J., Blazevic D. The composition of essential oil Vitex agnuscastus. Medica1992 Plant, 58 (Suppl 1): A681.10.Kubista E, Muller G, J. Spon conservative treatment of mastopathy. Zentralbl Gynakol. 1983, 105 (18): 115.362 .11. Lauritzen CH, Reuter HD, Repgen R. et al. Treatment of premenstrual tension syndrome with Vitex agnuscastus. Controlled, double blind versus pyridoxine. Phytomedicine 1997, 4: 183189.12.Loch EG, Bohnert KJ, Peeters M. et al. The treatment of menstrual disorders with Vitex tincture agnuscastus. Der Fraunarzt 1991, 32:867870 (translation) .13. Loch EG, Selle H, N. Boblitz treatment of premenstrual syndrome with a formulation containing Vitex agnus plant. J Women # 39; s Health Gend Based Med 2000 Apr; 9 (3): 31.520 .14. McKenna DJ, Jones K, Hughes K (eds). Botanical drugs: a desk reference for major herbal supplements. Haworth Press: New York15.Madaus Co. (1994). Agnolyt hormone imbalance naturally. Prospectus and the summary of research (translation) .16. Merz PG, Gorkow C, Schrodter A, Rietbrock S, Sieder C, Loew D, DericksTan JS, Taubert HD.The effects of a special Agnus castus extract (BP1095E1) on prolactin secretion in healthy men. Exp Clin Endocrinol Diabetes. 1996, 104 (6): 44.753 .17. Milewicz A, Gejdel E, Swor H, K Sienkiewicz, Jedrzejak J, T Teuch, Schmitz H. Vitex Agnus castus extract in the treatment of luteal phase defects due to latent hyperprolactinemia. The results of a randomized controlled trial doubleblind. Arzneimittelforschung. 1993 Jul; 43 (7): 7526 .18. Pepeljnjak S, A. Antolic Kustrak D. antibacterial and antifungal activities of extracts of Vitex L. agnuscastus. Acta Pharmaceutica (Zagreb) 1996, 46: 201206.19.Propping, D and T. Katzorke. 1987. The treatment of corpus luteum insufficiency. Zeitschrift f r Allgemeinmedizin 63:932933 (English translation) .20. Keep D., Bohnert KJ, Peeters M. et al. Agnuscastus Vitex treatment of gynecological syndromes. Therapeutikon 1991, 5:581585 (translation) .21. Reuter HD, Bohnert KJ, Schmidt U. The treatment of premenstrual syndrome with Vitex agnus: doubleblind controlled with pyridoxine. Zeitschrift f r Phytotherapie 1995, 7 (Abstracts volume): 7 (summary translation) .22. Roeder DA. Disorders Vitex agnuscastus cyclic therapy. F; rPhytotherapie1994 Zeitschrift, 15:155159 (English abstract) .23. Snow JM. Agnuscastus Vitex L. (Verbenaceae). Protocol Journal of Botanical Medicine (Spring) 1996; 2023.24.Turner S, Mills S. Doubleblind view a herbal remedy for premenstural syndrome: a case study. Complementary therapies in Medicine1993; 1:7377.25. Wuttke, W. Untersuchungen Zellbiologische MIMT Agnolyt Praparation (NH 246, NH 247). Keit Nlich Mittleilung Pers 1992; 8.7 (cited in Madaus Co., 1994) .26. Wuttke W, Gorkow C, Jarry H. Dopaminergic compounds in Vitex agnuscastus in: Loew, D. and N. Rietbrock (eds.), one klinischer Phytopharmaka Forschung und Anwendung. , 1995; Darmstatd, Germany: Steinkopff Verlag. 8191.27.Wuttke W, Splitt G, Gorkow C. et al. Treatment of cyclical mastalgia with Agnus castus: results of a randomized, placebocontrolled, doubleblind. Geburtshilfe und Frauenheilkunde 1997; NOTE 57:569574 (translation). EDITOR: This monograph can be found in the guide for health care of dietary supplements (Lippincott Williams Wilkins) Shawn M. Talbott, PhD and Kerry Hughes, MS. br br br br

Clinical studies indicate that women with endometriosis are very helpful in reducing their levels of estrogen

Clinical studies indicate that women with endometriosis are very helpful in reducing their levels of estrogen and increased progesterone levels. Herbs are effective in the treatment of endometriosis in Longhua Hospital, Shanghai 48 women diagnosed with endometriosis were treated with herbal medicines for 3 months. Doctors noticed significant improvements in symtops, with pregnancy rates to 26.7%! The same hospital treated 76 cases of endometriosis with herbs to improve blood circulation and experiencedsuccess rates of 80.26%. 88,89% of women no longer had dysmenorrhea, 66.72% were cured of pelvic pain, 72.12% were cured of pain during intercourse and 13.63% of getting pregnant. Meanwhile, doctors in Endocrinology and Reproductive Medicine, University of Vienna, said quot; botanical antiinflammatory drugs and analgesic properties and hold promise for the treatment of endometriosisquot, while there are many drugs in the labor market in hormone levels, which have side effects. I've listed a small sample below: Proveraside effects include anxiety, depression, swelling, dizziness, hunger, weight gain, fatigue, joint pains, insomnia, body odor, baldness, acne, edema, loss of bone density, cancer venous thrombosis, breast cancer and cervical cancer. Lupronside effects include weight gain, memory loss, decreased energy, insomnia, depression, loss of libido, hot flashes, edema, chest pain, rectal polyps, stroke, symptoms of fibromyalgia, the effects are increased Danazolside weight, acne, edema, vaginal dryness, hot flashes, hair loss, facial hair, deepening voice, enlarged clitoris, and even tumors in the liver and pancreatitis. Ita sad fact that women turn to their physicians for medical care are prescribing drugs that makes them feel worse. Fortunately, alternatives are not natural to these drugs. Herbs have been used for hundreds (and in some cases thousands) of years to help men and women conceive.What # 39; s more, modern research has confirmed that this work doubleblind herbs and herbs for clinical studies through the strictest and most vigorous testing, and have also confirmed these herbs help to think faster. These are just some of the results: ChasteberryChasteberry has been used for centuries in Western and Chinese medicine to treat gynecological diseases such as endometriosis. Combined with Dong Quai makes a powerful treatment for balancing hormones and reducing the pain of endometriosis. When combined with Wild Yam Chasteberry relaxes the uterus, reducing cramps and spasms. It is approved by the German Commission E for family physicians and gynecologists to use for the conditions of menstruation. In fact, a German study reported that 52% of women taking the herb reported a complete reduction of symptoms. Another German study reported 93% of women noted a significant decrease in PMS symptoms. Chasteberry is rich in essential oils and flavonoids. It works by stimulating the body to decrease estrogen levels and higher levels of progesterone, leading to changes in the reduction of endometriosis. Dong quai (Angelica sinensis) Dong Quai is also used in traditional Chinese medicine to treat female reproductive health problems such as endometriosis, fibroids, PMS and infertility. One study found that physicians in Taiwan Dong Quai inhibits tumor growth by 30%. The Chinese researchers found that Dong Quai polysaccharides enhance the immune system by activating T cells from New York University School of Medicine found that water soluble constituents in Dong Quai is an antiinflammatory and antibacterial properties of the Fourth Military efectocomercial.La Medical University in China found that Dong Quai prevented blood cells from clumping together and improve blood circulation. YamWild Wild Yam has been used in the West since the 18th century to treat menstrual cramps and other gynecological conditions such as endometriosis. It is rich in diosgenin, a substance used by the body to create progesterone. Wild Yam is effective in balancing estrogen levels, and researchers in Taiwan found that its phytoestrogens (a weak form of plant estrogen) bind to estrogen receptors in the body, replacing the most powerful and most dangerous of estrogen and xenoestrogens. Psychiatrists in China reported that Wild Yam reduces anxiety levels, and inflammatory and anti spasmodic effects are excellent for maintaining the health of the uterus. When combined with Vitex and cramp bark, Wild Yam is a powerful natural remedy for immediate relief of symptoms of endometriosis. Cramp Bark (Viburnum opulus) Cramp bark has been used for hundreds of years by Native Americans to treat muscle aches and cramps in the body. It is used to relax muscles, and is especially effective in smooth muscle cells of the uterus. It also has antiinflammatory and soothes, and calms nerves, reduces excessive bleeding and provides a relief for dysmenorrhea. It also has wonderful effects on irritable bowel syndrome and researchers from the National Medical University Lviv, Ukraine found an effective treatment of gastrointestinal damage. GingerGinger has been used for thousands of years in Chinese medicine to reduce nausea, reduce pain, treatment of digestive disorders and increase energy levels. It has been effectively used in India to enhance the allergic response, due to its antiinflammatory effect. Doctors at Bangkok, found that ginger reduces nausea and vomiting in pregnant patients, while scientists in Pakistan found that ginger enhance the travel of food through the intestine. It's also good for preventing endometrial tumors, and doctors at the Medical University of China, Taiwan showed that Ginger prevent the aggregation of blood cells. Researchers at Seoul National University also found that gingerol in ginger and vanilloids had antitumor properties. Echinacea (Dioscorea villosa) Echinacea helps fight against endometriosis, stimulating the immune system, helping the body get rid of stray endometrial cells, and by reducing inflammation and infection associated with endometriosis. Echinacea works by stimulating the immune response, promoting white blood cells to destroy foreign substances. Australian researchers found that it is also a powerful antioxidant. The beneficial effects of echinacea on the immune system is well documented, a study of Karl Franzens University, Austria has shown the effect of the herb in the innate and adaptive immune system. Research at the National College of Naturopathic Medicine, Portland, Oregon, also confirms this fact. Echinacea is used to improve the conditions caused by imbalances in the immune system. The University of Marche in Italy found safe and effective herb for treating patients suffering from an autoimmune disease. GoldensealGoldenseal has been used for hundreds of years by Native Americans for his fight against bacteria and antiinflammatory properties. It is particularly useful in endometriosis, which relaxes the muscles of the uterus, helps to reduce excessive bleeding, including bleeding between periods, bleeding and rupture of endometrial tumors. Its antibacterial effects have been documented by the University of Illinois, and berberine in goldenseal, along with Echinacea is effective in cleansing the body from infection and inflammation that can cause painful symptoms of endometriosis. Calendula Flower (Calendula officinalis) Calendula is highly effective in stimulating the immune system (especially in combination with Echinacea), connective tissue repair, and improve blood circulation. It is also a natural painkiller. Calendula is used to treat wounds, and is rich in plant antioxidants that protect the body from free radicals that damage cells. It also has antiinflammatory drugs, antibacterial and antiviral drugs, which are very useful to keep control of endometrial tumors. This is a great herb in any formula, because it improves the delivery of other herbs in the blood and lymphatic system, giving benefits faster and more efficient. br br br br